Finerenone Intermediates from India – Punagri Organics
Punagri Organics & Lifesciences Pvt. Ltd., the dedicated pharma-intermediates company of the Dama group, is a Finerenone intermediates manufacturer in India. In fact, we make five key Finerenone pharma intermediates that cover both building blocks of the commercial Finerenone route. As a result, generic API manufacturers, CDMOs and traders source from us as a dependable, quality-focused alternative to China.
- 5 intermediates, one supplier
- Backward-integrated aryl branch
- Vapi, Gujarat plant
- Lab scale to tonnage supply
- COA & MSDS with every batch
Finerenone, sold under the brand name Kerendia, is a non-steroidal mineralocorticoid receptor antagonist (MRA). Doctors use it in chronic kidney disease associated with type 2 diabetes and, more recently, in heart failure.
As generic development programmes gather pace, every API maker needs a steady supply of high-purity intermediates. First, this page explains what each intermediate does. Next, it shows why more buyers now source Finerenone intermediates from India. Finally, it explains why Punagri Organics aims to be the best Finerenone intermediate manufacturer in India.
What Are Finerenone Intermediates?
Finerenone intermediates are the chemical building blocks converted, step by step, into the final Finerenone API. The widely used commercial route builds the molecule from two halves that meet in a single ring-forming step.
First, 3-methoxy-4-methylbenzoic acid (CAS 7151-68-0) is converted into 4-cyano-2-methoxybenzaldehyde (CAS 21962-45-8), which carries the 4-cyano-2-methoxyphenyl group of Finerenone.
Next, the aldehyde condenses with 2-cyanoethyl acetoacetate (CAS 65193-87-5) to form a benzylidene keto-ester.
Meanwhile, 2-chloro-5-methylpyridine (CAS 18368-64-4) serves as the starting material for 4-amino-5-methylpyridin-2(1H)-one (CAS 95306-64-2).
Finally, the benzylidene keto-ester and the aminopyridinone cyclise to the dihydronaphthyridine core. This core is then O-ethylated, converted to the carboxamide and resolved to the (S)-enantiomer, Finerenone.
Because Punagri makes intermediates on both halves of the route, buyers can source the aldehyde, the keto-ester and the aminopyridinone from a single, audited supplier.
Our Finerenone Intermediates Portfolio
If you need specifications, click a linked product name to open its dedicated page.
| Product (chemical name) | CAS No. | Role in Finerenone synthesis |
|---|---|---|
4-Cyano-2-methoxybenzaldehyde (4-formyl-3-methoxybenzonitrile) | 21962-45-8 | Key aldehyde; supplies the 4-cyano-2-methoxyphenyl ring |
4-Amino-5-methylpyridin-2(1H)-one (4-amino-5-methylpyridin-2-ol) | 95306-64-2 | Aminopyridinone; forms the naphthyridine ring with the keto-ester |
2-Cyanoethyl 3-oxobutanoate (2-cyanoethyl acetoacetate) | 65193-87-5 | Keto-ester for the Knoevenagel condensation |
3-Methoxy-4-methylbenzoic acid (3-methoxy-p-toluic acid) | 7151-68-0 | Starting material for the aldehyde |
2-Chloro-5-methylpyridine (2-chloro-5-picoline) | 18368-64-4 | Starting material for the aminopyridinone |
If you need another grade, pack size or a custom-synthesis intermediate, send us your requirement.
Finerenone Intermediates in Detail
4-Cyano-2-methoxybenzaldehyde
4-Cyano-2-methoxybenzaldehyde, also called 4-formyl-3-methoxybenzonitrile, is the most important Finerenone intermediate on the aryl side. In addition, its aldehyde group drives the Knoevenagel condensation. Because its cyano and methoxy groups end up unchanged in the final API, its purity directly shapes the impurity profile of Finerenone.
View product page →
3-Methoxy-4-methylbenzoic Acid
3-Methoxy-4-methylbenzoic acid is the upstream raw material for CAS 21962-45-8. Our group has manufactured it for over 15 years, so it is one of our longest-running products. As a result, buyers who make the aldehyde in-house source it from us to secure the very start of the aryl branch. In addition, it is used in Zafirlukast synthesis.
View product page →4-Amino-5-methylpyridin-2(1H)-one
This aminopyridinone supplies the pyridine ring and the 8-methyl group of the Finerenone core. Since it reacts with the benzylidene keto-ester to close the dihydronaphthyridine ring, it is a key starting material (KSM) in most filed routes.
2-Cyanoethyl Acetoacetate
2-Cyanoethyl 3-oxobutanoate is the keto-ester partner for the aldehyde. Because the cyanoethyl ester can be cleaved under mild conditions later in the route, chemists choose it before the ester is converted to the carboxamide.
2-Chloro-5-methylpyridine
2-Chloro-5-methylpyridine is the starting material for the aminopyridinone (CAS 95306-64-2). Because it is also listed as a Finerenone related compound, we supply it with a full impurity profile for your analytical team.
Why 15 Years of CAS 7151-68-0 Manufacturing Matters
Those 15 years give us clear advantages across the Finerenone aryl branch:
Backward integration: because we make the starting material ourselves, the supply of CAS 21962-45-8 does not depend on an outside vendor.
A mature, proven process: years of commercial batches mean stable yields and a well-understood impurity profile that carries through to the aldehyde.
Cost control: since we own the first step, the cost of the downstream Finerenone intermediates stays competitive.
Simpler regulatory files: with one supplier from starting material to key intermediate, you have fewer vendors to qualify and a shorter, traceable route for your DMF.
Finerenone Intermediates from India: A Reliable Alternative to China
For years, much of the world’s supply of pharmaceutical intermediates came from China. However, supply shocks, freight disruptions and regulatory scrutiny are pushing buyers to a China+1 strategy, and India is the natural second source for Finerenone intermediates.
| Sourcing Factor | What India Offers |
|---|---|
Supply security | A qualified second source in India reduces the risk of a single-country disruption halting your API line. |
Regulatory familiarity | A deep base of US FDA- and EU-inspected API sites; Indian suppliers are used to providing DMF-ready documentation. |
Transparent communication | English-language technical teams and overlapping business hours with Europe, the Middle East and Asia make audits and change control easier. |
Competitive cost | A mature chemical cluster keeps raw material and conversion costs competitive without trading off quality. |
Integrated ecosystem | Buyers who also make Finerenone API or formulations in India can shorten lead times by sourcing intermediates locally. |
If you are qualifying Finerenone intermediates as an alternative to China, Punagri can support your vendor qualification with samples, analytical data and audit access. Also, if you source anticoagulant intermediates, see our Apixaban intermediates manufacturer in India page.
Why Punagri Organics Is the Best Finerenone Intermediate Manufacturer in India
Punagri Organics & Lifesciences is a plant in Vapi, Gujarat, built only for pharma intermediates. It was commissioned in 2025. Moreover, it is backed by Jay Finechem’s process experience since 1989. Both companies are owned and managed by the Dama family.
| Facility | Details |
|---|---|
Location | Vapi, Gujarat; a plant built only for pharma intermediates |
Commissioned | 2025 (production started in July 2025) |
Permitted capacity | 515 MT per month of APIs and intermediates, including 7 MT per month reserved for new development molecules |
Multi-purpose plant | 15 MSGL and 13 SS316 reactors (100 L–8 KL, about 111 KL in total) |
Catalytic hydrogenation | 3 hydrogenators (250 L–5 KL) |
Operating range | −20 to 190 °C and up to 50 kg/cm²g |
Clean-room finishing | Mini production plant with an ISO Class-8 clean room for high-purity final steps |
Process control | Yokogawa DCS |
In-house QC | HPLC, GC with headspace, FT-IR, UV-Vis and Karl Fischer titration |
Effluent treatment | 185 KLD effluent treatment plant with zero liquid discharge; environmental clearance and permits in place |
Five intermediates, one supplier: from the starting materials (CAS 7151-68-0 and 18368-64-4) to the key aldehyde and aminopyridinone (CAS 21962-45-8 and 95306-64-2), we consolidate vendors and simplify audits.
Consistent quality: each batch is released against a Certificate of Analysis with HPLC purity ≥99.0% and controlled impurity limits.
GMP-oriented quality system: SOPs, vendor qualification, computer system validation, analytical method and cleaning/process validation, change control and CAPA.
Export experience: we ship worldwide by air or sea, so your supply chain stays flexible.
Quality, Documentation and Global Export
Since regulated buyers need complete paperwork, every shipment of Finerenone intermediates from Punagri comes with the documents below.
| Document | What It Covers | Availability |
|---|---|---|
Certificate of Analysis (COA) | HPLC purity, assay, moisture and related substances | Every batch |
MSDS / SDS | Safe handling, storage and transport information | Every shipment |
Route of synthesis & impurity profile summary | For DMF and regulatory filings | Under NDA |
Audit & vendor questionnaire support | Customer audits and qualification | On request |
In addition, we pack to your specification and ship by air or sea under EXW, FOB or CIF terms from Indian ports.
Frequently Asked Questions about Finerenone Intermediates
What are the key intermediates of Finerenone?
The key Finerenone intermediates are 4-cyano-2-methoxybenzaldehyde (CAS 21962-45-8), 4-amino-5-methylpyridin-2(1H)-one (CAS 95306-64-2) and 2-cyanoethyl acetoacetate (CAS 65193-87-5), with 3-methoxy-4-methylbenzoic acid (CAS 7151-68-0) and 2-chloro-5-methylpyridine (CAS 18368-64-4) as starting materials. In addition, Punagri Organics manufactures all five.
What is the CAS number of 4-cyano-2-methoxybenzaldehyde?
4-Cyano-2-methoxybenzaldehyde (4-formyl-3-methoxybenzonitrile) is CAS 21962-45-8. Because it supplies the 4-cyano-2-methoxyphenyl group of Finerenone, it is the key aryl-side intermediate.
Who is the best Finerenone intermediate manufacturer in India?
Punagri Organics & Lifesciences, part of the Jay Finechem group, is a dedicated Finerenone intermediate manufacturer in Vapi, India. Since we supply five intermediates across both halves of the route, buyers also get full COA, MSDS and regulatory support.
Can India replace China as a source of Finerenone intermediates?
Yes. In fact, many buyers now qualify Finerenone intermediates from India as an alternative to China to secure supply, with comparable cost and strong regulatory documentation.
What is Finerenone used for?
Finerenone (Kerendia) is a non-steroidal mineralocorticoid receptor antagonist. Doctors use it in chronic kidney disease associated with type 2 diabetes and, more recently, in heart failure.
Do you supply samples of Finerenone pharma intermediates?
Yes. We supply samples with a COA for evaluation and vendor qualification. To get started, contact us with your required CAS numbers and quantities.
What is the minimum order quantity?
From lab scale to tonnage level, we can support all scales.
Is 3-methoxy-4-methylbenzoic acid used for anything besides Finerenone?
Yes. Besides Finerenone, it is also used in Zafirlukast synthesis. Our group has made it for over 15 years.
Request a Quote for Finerenone Intermediates
If you are looking for a reliable Finerenone intermediates supplier from India, send us the CAS numbers, quantities and destination country. Then our team will reply with pricing, lead time and a sample COA within 24 hours.