Apixaban Intermediates from India – Punagri
Punagri is an Apixaban intermediates manufacturer in India, supplying seven key Apixaban pharma intermediates that cover the main stages of the most widely used Apixaban synthesis routes. As a result, generic API manufacturers, CDMOs and traders worldwide source from us as a dependable, quality-focused alternative to China.
- 7 intermediates, one supplier
- HPLC purity ≥99.0%
- ISO · GMP · DUNS
- Gram to tonnage supply
- COA & MSDS with every batch
Demand for Apixaban, the oral anticoagulant sold under the brand name Eliquis, keeps rising as generic versions launch across regulated and emerging markets. For this reason, every generic API maker needs a steady supply of high-purity intermediates to meet that demand.
First, this page explains what each intermediate is. Next, it shows why more buyers now source Apixaban intermediates from India. Finally, it explains why Punagri aims to be the best Apixaban intermediate manufacturer in India.
What Are Apixaban Intermediates?
Apixaban intermediates are the chemical building blocks that are converted, step by step, into the final Apixaban API. The final drug is a direct factor Xa inhibitor used to prevent stroke in atrial fibrillation and to treat and prevent deep vein thrombosis and pulmonary embolism.
Most commercial Apixaban routes join two halves of the molecule:
First, ethyl (Z)-2-chloro-2-(2-(4-methoxyphenyl)hydrazineylidene)acetate (CAS 27143-07-3) supplies the hydrazone half.
Next, a morpholino-dihydropyridinone on a substituted phenyl ring is made via the nitro (503615-03-0), amino (1267610-26-3) or iodo (473927-69-4) intermediates, leading to 545445-44-1.
Finally, the two halves cyclise into the pyrazolo[3,4-c]pyridine ester: the nitro ester (536759-91-8) or Apixaban ethyl ester (503614-91-3), the last intermediate before amidation to Apixaban.
Because Punagri makes intermediates across all three stages, buyers can source several steps of their route from a single, audited supplier.
Our Apixaban Intermediates Portfolio
If you need specifications, click any product name to open its dedicated page.
| Product (chemical name) | CAS No. | Route Stage |
|---|---|---|
Ethyl (Z)-2-chloro-2-(2-(4-methoxyphenyl)hydrazineylidene)acetate | 27143-07-3 | Hydrazone half (KSM) |
503615-03-0 | Lactam half – nitro | |
1267610-26-3 | Lactam half – amino | |
473927-69-4 | Lactam half – iodo | |
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one | 545445-44-1 | Advanced lactam |
536759-91-8 | Coupled core – nitro ester | |
503614-91-3 | Penultimate intermediate |
If you need another grade, pack size or a custom-synthesis intermediate, send us your requirement.
Apixaban Intermediates in Detail
Apixaban Ethyl Ester
As the penultimate Apixaban intermediate, Apixaban ethyl ester is converted to the API in a single amidation step. Because its purity directly drives the impurity profile of the final API, we control related substances tightly at this stage. In addition, it is our most-requested product from generic API manufacturers.
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Hydrazonoyl Chloride
This intermediate supplies the methoxyphenyl-pyrazole half of Apixaban. Since it is a key starting material (KSM) in most routes, a dependable source of this Apixaban pharma intermediate protects your whole production schedule.
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Advanced Lactam
Because it already carries the piperidinone ring, it couples with CAS 27143-07-3 to form Apixaban ethyl ester, which shortens your in-house process.
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Nitro Lactam
As an early lactam building block, it supports the nitro-reduction route, where the nitro group is reduced to the amine before the piperidinone ring is built.
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Amino Lactam
It supports the direct amino route, so you can skip the nitro-reduction step in your own plant.
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Iodo Lactam
This intermediate supports the iodo coupling route. Because we also offer the nitro and amino lactams, you can follow whichever route your DMF is filed on.
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Nitro Pyrazolopyridine Ester
In the nitro route, this coupled core is reduced and then cyclised to give the piperidinone ring before amidation.
View product page →Apixaban Intermediates from India: A Reliable Alternative to China
For years, much of the world’s supply of pharmaceutical intermediates came from a single country. However, recent supply shocks, freight disruptions and regulatory scrutiny have pushed buyers to adopt a China+1 strategy, and India is the natural second source for Apixaban intermediates.
| Sourcing Factor | What India Offers |
|---|---|
Supply security | A second, qualified source in India reduces the risk of a single-country disruption halting your API line. |
Regulatory familiarity | A deep base of US FDA- and EU-inspected API sites; Indian suppliers are used to providing DMF-ready documentation. |
Transparent communication | English-language technical teams and overlapping business hours with Europe, the Middle East and Asia make audits and change control easier. |
Competitive cost | A mature chemical cluster keeps raw material and conversion costs competitive without trading off quality. |
Integrated ecosystem | Buyers who also make Apixaban API or formulations in India can shorten lead times by sourcing intermediates locally. |
If you are qualifying Apixaban intermediates as an alternative to China, Punagri can support your vendor qualification with samples, analytical data and audit access.
Why Punagri Is the Best Apixaban Intermediate Manufacturer in India
Because Punagri focuses on a few complex molecules, we do each one very well, and Apixaban intermediates are a core part of that focus.
Seven intermediates, one supplier: from the KSM (CAS 27143-07-3) to Apixaban ethyl ester (CAS 503614-91-3), consolidating vendors and simplifying audits.
In-house process development: because our chemists developed these routes internally, we can adapt specifications to your DMF.
Consistent quality: each batch is released against a Certificate of Analysis with HPLC purity ≥99.0% and controlled impurity limits.
Scalable capacity: we scale from gram-scale samples to commercial supply from our facility in Vapi, Gujarat.
Certifications: ISO, DUNS, GMP.
Export experience: we ship to Europe, Japan, China and Korea.
Quality, Documentation and Global Export
Since regulated buyers need complete paperwork, every shipment of Apixaban intermediates from Punagri comes with the documents below.
| Document | What It Covers | Availability |
|---|---|---|
Certificate of Analysis (COA) | HPLC purity, assay, moisture and related substances | Every batch |
MSDS / SDS | Safe handling, storage and transport information | Every shipment |
Method of analysis & specification sheet | Test methods and acceptance limits | On request |
Route of synthesis & impurity profile summary | For DMF and regulatory filings | Under NDA |
Audit & vendor questionnaire support | Customer audits and qualification | On request |
Frequently Asked Questions about Apixaban Intermediates
What are the key intermediates of Apixaban?
The key Apixaban intermediates are the hydrazonoyl chloride (CAS 27143-07-3), the morpholino-dihydropyridinone lactams (CAS 503615-03-0, 1267610-26-3, 473927-69-4, 545445-44-1) and the pyrazolopyridine esters (CAS 536759-91-8 and Apixaban ethyl ester, CAS 503614-91-3). In addition, Punagri manufactures all seven.
What is the CAS number of Apixaban ethyl ester?
Apixaban ethyl ester is CAS 503614-91-3. Because it is the penultimate intermediate, it is converted to Apixaban by a single amidation.
Who is the best Apixaban intermediate manufacturer in India?
Punagri is a specialist Apixaban intermediate manufacturer in India, supplying seven intermediates across the synthesis route with full COA, MSDS and regulatory support.
Can India replace China as a source of Apixaban intermediates?
Yes. In fact, many buyers now qualify Apixaban intermediates from India as an alternative to China to secure supply, with comparable cost and strong regulatory documentation.
Do you supply samples of Apixaban pharma intermediates?
Yes. We supply samples with a COA for evaluation and vendor qualification. To get started, contact us with your required CAS numbers and quantities.
What is the minimum order quantity?
From gram level to tonnage level, we can support.
Request a Quote for Apixaban Intermediates
If you are looking for a reliable Apixaban intermediates supplier from India, send us the CAS numbers, quantities and destination country. Then our team will reply with pricing, lead time and a sample COA within an hour.