Trusted Key Starting Material (KSM) Manufacturers in India

At Punagri Organics & Lifesciences, we are the top Key Starting Material Manufacturers in India. We make Key Starting Materials for the pharmaceutical industry. Our materials are high-quality, safe, and meet global standards. We focus on consistency so every batch performs the same.

Whether you make generic drugs or new medicines, our KSM gives your process a strong foundation. We work closely with clients to match their specific formulation needs. Each product is developed to ensure smooth integration into your production process.

Our Focus: Quality, Reliability & Global Compatibility

We understand how important dependable starting materials are to Pharmaceutical manufacturing. That is why we make sure that every batch meets strict quality benchmarks, supports smooth scale-up, and performs reliably in real-world production.

  • Reliable outcomes: Each material is produced with batch-to-batch consistency

  • Built for global use: Our processes meet international quality expectations

  • Backed by science: In-house R&D ensures product stability and process understanding

  • End-to-end traceability: Every lot is documented and traceable

Our manufacturing unit meets strict GMP and WHO-GMP standards to support regulatory confidence across global markets.

What We Offer

Custom KSM Synthesis
We develop and supply Key Starting Materials based on specific client needs. We handle everything from small batches to bulk production. Our process makes sure the switch from development to delivery is smooth.

High-Purity Intermediates
All products are manufactured with a strong focus on purity, minimal impurities, and repeatable performance. We help clients avoid batch failures or unexpected delays.

Process & Analytical Support
Our team supports scale-up, tech transfer, and documentation to ensure your production runs are efficient and well-documented across regions.

Strong Packaging & Global Supply Chain Support
At Punagri, we know that quality doesn’t stop at manufacturing. That is why we pay close attention to how our Key Starting Materials are packaged and handled. Our packaging processes are designed to preserve product integrity from production to final delivery. Each material is sealed in chemically compatible containers that prevent contamination and maintain stability. We follow clear labelling practices with batch details, safety data, and handling instructions to support safe and traceable usage. Whether it is a small batch or a large order, we handle it with care. Every unit is packaged properly and meets industry standards.

Who We Work With

  • We work with Pharmaceutical companies and research organizations worldwide and provide reliable Key Starting Materials for various segments:

    • Drug development and scale-up: Supporting smooth transitions from R&D to pilot and commercial production with consistent, high-quality intermediates.

    • API manufacturing: Supplying stable KSMs that integrate seamlessly into API synthesis for both innovator and generic drug makers.

    • Custom synthesis and contract manufacturing: Partnering with CDMOs and CROs for route-specific intermediates and tailored material development.

    • Life sciences and health product innovation: Enabling R&D and early-stage production with reliable raw materials designed to meet performance and quality needs.

    Our clients operate globally, and so do we. With each partnership, we bring a clear understanding of documentation, regulatory expectations, and product traceability. We ensure smooth supply across regulated and semi-regulated markets.

Why Work with Punagri?

We are committed to long-term partnerships built on consistent product quality, timely delivery, and transparent collaboration. Our goal is to help our partners achieve smooth operations and regulatory success that also without any delays or rework.

If you are looking for dependable KSM manufacturers that deliver globally compatible, high-quality intermediates, Punagri Organics & Lifesciences is here to support your pharmaceutical success.

Frequently Asked Questions (FAQs)

 A KSM starts the API process, while intermediates appear during later synthesis steps.

The right KSM affects API yield and purity. Punagri ensures consistent quality across all materials.

Yes, global agencies like EMA offer guidance on selecting and documenting KSMs in development.

 Yes, some KSMs are used across APIs depending on process chemistry and regulatory needs.

Punagri offers trusted service, global standards, and stands out among leading KSM manufacturers for reliable supply.

Structures Pharma Intermediates CAS number Application Area
1-Iodo-4-nitrobenzene
636-98-6

Apixaban, Dapsone, Vibegron

1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
1067610-26-3

Apixaban

1-(4-Aminophenyl)-4-(4-hydroxyphenyl)- piperazine
74,853.00
74853-08-0

Posaconazole

1-Cyclohexyl piperazine
17766-28-8

Avatrombopag

2-(Bromoethyl)phthalimide
574-98-1

Ensifentrine, Lapatinib

2-bromo-5-methoxyaniline
59557-92-5

Pharma Intermediate

2-Nitro-5-phenylthioaniline
43156-47-4

Oxfendazole

CAS 1820-80-0 3-Aminopyrazole
1820-80-0

Apixaban

CAS 503615-03-0 product from Punagri
503615-03-0

Apixaban

4-Amino-2-methylbenzoic Acid product from Punagri
2486-75-1

Tolvaptan

4-Cyclopentylpiperazin-1-amine
61379-64-4

Rifapentine

4-Glycidyloxycarbazole

N/A

5-Ethyl-2-methylpyridine from Punagri
104-90-5

Etoricoxib

Aminoguanidine bicarbonate
2582-30-1

Lamotrigine, Capmatinib

Homocysteine thiolactone hydrochloride structure from Punagri
6038-19-3

Erdosteine

N-(4-Bromophenyl)benzenepropanamide
316146-27-7

Bedaquiline

2-Chloro-5-Nitro Toluene
2,000.00
13290-74-9

Ponazuril/ Toltrazuril

CAS 82104-74-3 5-Cyanophthalide
82104-74-3

Citalopram, Escitalopram

Cyanodiol Hbr
2,000.00
103146-26-5

Citalopram, Escitalopram

Cyanodiol HCl
2,000.00
717133-25-0

Citalopram, Escitalopram

Cyanodiol Base
2,000.00
103146-25-4

Citalopram, Escitalopram

3-Methoxy-4-methylbenzoic acid
2,000.00
7151-68-0

Zafirlukast, Finerenone

4-Cyano-2-methoxybenzaldehyde
2,000.00
21962-45-8

Finerenone

CAS 5401-94-5 5-Nitroindazole
2,000.00
5401-94-5

BMS-599626, Belumosudil

3,4-Dihydroxy-5-nitrobenzaldehyde
2,000.00
116313-85-0

Entacapone

Ethyl 2-Aminothiazole-5-carboxylate CAS 32955-21-8
2,000.00
32955-21-8

Dasatinib, Ceftibuten

2-Chloro-6-methylaniline CAS 87-63-8
2,000.00
87-63-8

Dasatinib, Duvelisib

CAS 540-51-2 2-Bromoethanol
2,000.00
540-51-2

Umeclidinium Bromide, Citicoline, Quetiapine

2-Amino-5-methylthiazole CAS 7305-71-7
Original price was: ₹2.00.Current price is: ₹1.00.
7305-71-7

Meloxicam

5-Nitroisophthalic Acid structure from Punagri
Original price was: ₹2,000.00.Current price is: ₹12.00.
618-88-2

Iohexol, Iopamidol

3-Nitrobenzaldehyde
2,000.00
99-61-6 

Lercanidipine, Nicardipine, Cilnidipine

Dimethyl Anthranilate structure from Punagri
2,000.00
85-91-6

Dibenzepin

CAS 133-91-5 3,5-Diiodosalicylic Acid
2,000.00
133-91-5

Rafoxanide

1,4-Dimethoxybenzene
2,000.00
150-78-7

Midodrine hydrochloride

4-Methoxyphenol
2,000.00
150-76-5

Tiratricol , Levothyroxine, Azelaic Acid

4-Methoxy-2-nitroaniline
2,000.00
96-96-8

Omeprazole Sodium, Primaquine Phosphate

5-Aminoindazole
2,000.00
19335-11-6

Belumosudil Mesylate

6-Nitroindazole
2,000.00
7597-18-4

Axitinib

3-Iodo-6-nitroindazole
2,000.00
70315-70-7

Axitinib

2-Methyl-5-nitroaniline
2,000.00
99-55-8

Imatinib

4-Ethylphenol
2,000.00
123-07-9

Ambroxol / Sorafenib

4-(2,3-epoxypropoxy)-carbazole
2,000.00
51997-51-4

Carvedilol

2-(2-methoxyphenoxy) ethylamine
2,000.00
1836-62-0

Amosulalol, Carvedilol

tert-Butyl carbazate
2,000.00
870-46-2

Ibrutinib/ Olaparib / Gliclazide

CAS 42142-52-9 N-Methyl-3-phenyl-3-hydroxypropylamine
2,000.00
42142-52-9

Atomoxetine, Fluoxetine

5-Nitroindole
2,000.00
6146-52-7

Zafirlukast

N-Methylformanilide
2,000.00
93-61-8

Fluvastatin sodium

CAS 99-31-0 5-Aminoisophthalic Acid
Original price was: ₹23.00.Current price is: ₹12.00.
99-31-0

Iohexol

5-Nitrovanillin
2,000.00
6635-20-7

Entacapone

4-Bromo-1-methyl-1H-pyrazole
2,000.00
15803-02-8

BIT-225 / Savolitinib

Benzylhydrazine dihydrochloride
2,000.00
20570-96-1

Heterocyclic amides as inhibitors of receptor interacting protein kinase 1 (RIPK1)

α-Pinene oxide
2,000.00
1686-14-2

Sobrerol

Methyl-3-cyanobenzoate
2,000.00
13531-48-1

Ataluren

1-(2-methyl-5-nitrophenyl)-guanidine nitrate
2,000.00
152460-08-7

Imatinib

2-Amino-6-thiocyanato -benzothiazole
2,000.00
7170-77-6

c-Met kinase inhibitor, SAR-125844

4-Nitroguaiacol
2,000.00
3251-56-7

Gefitnib, SB-568849

Isopropyl-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide
2,000.00
118854-48-1

Meloxicam

2-Methyl-4-nitroaniline
2,000.00
99-52-5

Tolvaptan

2-Chloro-2',6'-dimethylacetanilide
2,000.00
1131-01-7

Lidocaine / Ranolazine

2-[(3,5-Dimethylphenoxy)methyl]oxirane
2,000.00
4287-30-3

Metaxalone

4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile oxalate
717133-32-9

Escitalopram

1-Amino-3-(3,5-dimethylphenoxy)propan-2-ol
66766-07-2

Metaxalone

2-Chlorobenzimidazole
2,000.00
4857-06-1

Emedastine, Lansoprazole, Mizolastine

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide
5294-61-1

Ranolazine

1-(2-Methoxyphenoxy)-2,3-epoxypropane
2,000.00
2210-74-4

Methocarbamol / Ranolazine

3-(3,5-dimethylphenoxy)propane-1,2-diol
2,000.00
59365-66-1

Metaxalone

5-Aminoindole
2,000.00
5192-03-0

HIV protease inhibitors / Anti-cancer agent

2-Bromo-4-nitroanisole
2,000.00
5197-28-4

Pharma intermediate

1,3-Indanedione
606-23-5

Pharma intermediate

2-chloro-5-methoxyphenol
2,000.00
18113-04-7

Pharma intermediate

N-tert-Butyl piperazine
2,000.00
38216-72-7

Pharma intermediate

N-tert-Butyldiethanolamine
2160-93-2

Pharma intermediate

4-Fluoro-2-methylaniline
2,000.00
452-71-1

Pharma intermediate

2-Amino-4-methoxy-phenol
2,000.00
20734-76-3

Iguratimod

Structure of Product with CAS 461432-23-5 from Punagri
2,000.00
461432-23-5

Dapagliflozin / Empagliflozin

(S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran | Empagliflozin Intermediate
2,000.00
915095-89-5

Empagliflozin

structure of 915095-94-2 Manufacturer - Punagri
2,000.00
915095-94-2

Empagliflozin

(Z)-Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
2,000.00
27143-07-3

Apixaban

CAS 330786-24-8 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
2,000.00
330786-24-8

Ibrutinib

CAS 1383385-64-5 Acalabrutinib Intermediate
2,000.00
1383385-64-5

Acalabrutinib

2-(4-fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene
2,000.00
898566-17-1

Canagliflozin

4-(Pyridin-2-yl)aminocarbonylphenylboronic acid
2,000.00
850568-25-1

Acalabrutinib

Methyl 3-Amino-5-bromo-2-methylbenzoate
2,000.00
1000342-11-9

Tazemetostat

CAS 330792-70-6 Ibrutinib Intermediate
2,000.00
330792-70-6

Ibrutinib / Zanubrutinib

1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene
2,000.00
1103738-29-9

Sotagliflozin/ Dapagliflozin

2-Phenylbutyric acid
2,000.00
90-27-7

Butamirate Citrate / Indobufen

Ethyl lauroyl arginate HCl
2,000.00
60372-77-2

Cosmetic additive

5,6-Dimethoxy indanone
2,000.00
2107-69-9

Donepezil

5-Methylisoxazole-4-carboxylic acid
2,000.00
42831-50-5

Leflunomide/ Teriflunomide

4-Phenylbutyric acid
2,000.00
1821-12-1

Cosmetic additive

Tropic acid
2,000.00
552-63-6

Atropine/ Ipratropium bromide

Homoveratric acid
2,000.00
93-40-3

Papaverine/ Ivabradine

4-Hydrazinobenzoic acid
2,000.00
619-67-0

Deferasirox

1-Indanone
2,000.00
83-33-0

Indinavir/ Rasagiline

4-Bromo-3-nitroanisole
2,000.00
5344-78-5

Elacestrant

N-Methyl-3,3-diphenylpropan-1-amine hydrochloride
29768-15-8

Lercanidipine

CAS 1339391-39-7 1-(Oxan-4-yl)-1H-pyrazol-3-amine
1339391-39-7

Dorzagliatin

53207-00-4 product from Punagri
53207-00-4

Ivabradine, Pinaverium

6-Chloro-m-anisidine
2,000.00
2401-24-3

Pilaralisib

1 2